Sero-prevalence and factors associated with anti-Brucella antibodies in slaughter livestock in Uganda

Introduction Brucellosis is endemic in Uganda and a major cause of production losses livestock. Early detection quantification the disease vital for its control eradication. The aim this study was to assess sero-prevalence factors associated with anti- Brucella antibodies slaughtered Materials methods Sera from 886 cattle, 925 small ruminants, 900 pigs were collected regional abattoirs Northern, Eastern Central Uganda. To estimate sero-prevalence, sera serially tested using combination Rose Bengal Test (RBT) Native Hapten (NH) immunoprecipitation test. True estimated Rogan-Gladden estimator considering sensitivity specificity NH Multivariable logistic regression used seropositivity antibodies. Results discussion Small ruminants showed highest seroprevalence (6.7%, 95% CI = 4.2-7.1) followed by cattle (3.8%, 2.4-4.9) (2.8%, 1.1-2.9). Seropositivity region origin (OR 4.6,95%CI=1.49-17.75, p 0.013) cattle; sex 2.90, C 1.5-6.34, 0.004), age (OR=4.04, 1.07-8.52, 0.006) species 2.53, 1.08-6.98, 0.048) ruminants; finally 2.88, 0.041). Progressive interventions must include both since they play bigger role maintenance dissemination . should adopt risk-based approach regions at higher risk being given top priority. Bacteriological molecular studies be undertaken clarify goat-cattle cross infections epidemiological cycle brucellosis